Interleukin-17 governs hypoxic adaptation of injured epithelium [spatial transcriptomics]
Summary:To define the gene signature and spatial architecture of the skin after injury, we performed spatial transcriptomics from mouse unwounded and wounded skin.
Overall design:Wild type (unwounded, wounded) and GFP-KI (wounded) skin were fresh frozen and sectioned at 10um thickness onto spatial transcriptomics (ST) slides for mRNA capture, followed by library preparation and sequencing. The GFP-KI genotype disrupts the Rorc gene.
Citation:Konieczny, Piotr et al. “Interleukin-17 governs hypoxic adaptation of injured epithelium.” Science (New York, N.Y.) vol. 377,6602 (2022): eabg9302. doi:10.1126/science.abg9302
Submission date: 2021-02-17Update date: 2021-02-22
Piotr Konieczny; Xing Yue; Ikjot Sidhu; Shruti Naik
AccessionsGEO Series Accessions: GSE166948