Interleukin-17 governs hypoxic adaptation of injured epithelium [spatial transcriptomics]
Dataset ID: STDS0000089
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PMID:35709248
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3,909 Spots
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32,285 Genes
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Dataset information
Contributors
Accessions
Dataset information
Summary:
To define the gene signature and spatial architecture of the skin after injury, we performed spatial transcriptomics from mouse unwounded and wounded skin.
Overall design:
Wild type (unwounded, wounded) and GFP-KI (wounded) skin were fresh frozen and sectioned at 10um thickness onto spatial transcriptomics (ST) slides for mRNA capture, followed by library preparation and sequencing. The GFP-KI genotype disrupts the Rorc gene.
Technology:
10x Visium
Platform:
GPL24247
Species:
Mus musculus(mm10)
Tissues:
Skin
Disease:
Injured skin
Citation:
Konieczny, Piotr et al. “Interleukin-17 governs hypoxic adaptation of injured epithelium.” Science (New York, N.Y.) vol. 377,6602 (2022): eabg9302. doi:10.1126/science.abg9302
Submission date: 2021-02-17Update date: 2021-02-22
Contributors
Piotr Konieczny; Xing Yue; Ikjot Sidhu; Shruti Naik
Contact: Shruti.Naik@nyulangone.org
Accessions
GEO Series Accessions: GSE166948