Solanum ptychanthum, West Indian nightshade or eastern black nightshade, is an annual or occasionally perennial plant in the Solanaceae (Nightshade) family. It is typically 15–60 cm tall and many branched.

The leaves of eastern black nightshade are triangular to elliptic. The stems are circular, and sometimes slightly hairy. The flowers are small, white, and star-shaped, and they occur in small umbels of 5-7. The flowers ripen into glossy, black berries, each 10 mm in diameter and containing between 50 and 100 seeds. The ripened fruits have been shown to be not poisonous in low to moderate amounts, however the unripened berries are toxic. The berries are eaten and dispersed by birds.