CIRSTA: Cholestatic Injury and Repair Spatio-Temporal Atlas

Cholestatic injuries, characterized by regional damage around the periportal region, lack curative therapies and cause considerable mortality. In this study, we generated a high-definition spatiotemporal atlas during cholestatic injury and repair by Stereo-seq and single-cell transcriptomics. We uncovered that cholangiocytes function as a periportal hub (cholangio-hub) by integrating multiple signals with neighboring cells. Feedback between cholangiocytes and lipid-associated macrophages (LAM) was detected in the cholangio-hub, which is related to the differentiation of LAM, a recently identified subpopulation of macrophages crucial in tissue injury.

Release at 2024-04-16

Wu, B., Shentu, X., Nan, H., Guo, P., Hao, S., Xu, J., ... & Hui, L. (2024). A spatiotemporal atlas of cholestatic injury and repair in mice. Nature Genetics, 1-15. DOI: 10.1038/s41588-024-01687-w