Genos: Genomic Foundation Model
As the leading basic model in the field of human genome, Genos relies on massive high-quality genomic benchmark data for in-depth training,Its innovation lies in the breakthrough realization of the human genome sequence up to million base pairs of Context modeling ability. Through single-base resolution learning, the model successfully analyzes the deep sequence rules and functional characteristics hidden in the genome, and constructs an intelligent bridge connecting genetic information and life activities.

RNA Coverage Track Prediction
This feature leverages the extensive pre-training of the Genos foundation model on genomic data to predict single-base-resolution RNA-seq expression profiles directly from DNA sequences, spanning multiple cell types and tissues. It establishes a direct mapping between genomic sequence and transcriptomic expression, facilitating the understanding of gene-regulatory mechanisms and accelerating transcriptomic research. The input is a point of the hg38 reference genome; the output is the average, normalized RNA-seq signal value (single-base precision) for each genomic position of a 32Kbp region, on both the positive and negative strands in various cell types.
Usage
Follow the 2 steps below to select and submit a start point to generate signal intensity and gene list of target 32Kbp region started with the start point.
  1. Select or change a start point in the genome browser. There are several ways to achieve, feel free to combine the operations:
    • Click on the ideogram directly.
    • Click the arrow buttons to move backward or forward. Click the magnifier buttons to zoom in or zoom out.
    • Input a region (eg. chrX:123-789) in the input field, then press Enter key to confirm.
    • Move the mouse over the ruler bar (the bar below the input field) to select a region, then click "Zoom to region" to confirm.
    • Drag to left or right on any track (eg. "NCBI RefSeq Genes" track).
  2. Submit and wait for result for several seconds.
Usage
Current start point: chr19:39,407,000