Full name: extra spindle pole bodies like 1, separase

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: ESP1; SEPA

Summary: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]

Expression: Biased expression in esophagus (RPKM 7.6), testis (RPKM 5.7) and 12 other tissues

Gene size: 25340bp

Exon count: 32