EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 9695)
Source: NCBI Gene (ID 9695)
Symbol: EDEM1
Full name: ER degradation enhancing alpha-mannosidase like protein 1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Also known as: EDEM
Summary: Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity and misfolded protein binding activity. Involved in mannose trimming involved in glycoprotein ERAD pathway; positive regulation of retrograde protein transport, ER to cytosol; and protein targeting to ER. Located in aggresome and endoplasmic reticulum quality control compartment. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bone marrow (RPKM 22.7), lymph node (RPKM 21.0) and 25 other tissues
Orthologs: mouse
Gene size: 32252bp
Exon count: 14