Edem1 ER degradation enhancer, mannosidase alpha-like 1 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 192193)
Source: NCBI Gene (ID 192193)
Symbol: Edem1
Full name: ER degradation enhancer, mannosidase alpha-like 1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: A130059K23Rik; EDEM; mKIAA0212
Summary: Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in positive regulation of retrograde protein transport, ER to cytosol and trimming of terminal mannose on C branch. Acts upstream of or within ubiquitin-dependent ERAD pathway. Is integral component of endoplasmic reticulum membrane. Is expressed in embryo and liver. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 71.9), liver adult (RPKM 21.5) and 21 other tissues
Orthologs: human
Gene size: 35334bp
Exon count: 13