Full name: cadherin EGF LAG seven-pass G-type receptor 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2

Summary: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]

Expression: Broad expression in kidney (RPKM 10.0), skin (RPKM 8.2) and 16 other tissues

Gene size: 176447bp

Exon count: 38