MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 [ Homo sapiens (human) ] - Gene - Data resources

9448

MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 9448)

Symbol: MAP4K4

Full name: mitogen-activated protein kinase kinase kinase kinase 4

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: FLH21957; HEL-S-31; HGK; MEKKK4; NIK

Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in brain (RPKM 42.7), fat (RPKM 25.1) and 23 other tissues

Orthologs: mouse

Gene size: 196984bp

Exon count: 33