Full name: ubiquitin like modifier activating enzyme 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: NAE2; UBE1C; hUBA3

Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in heart (RPKM 24.5), lymph node (RPKM 24.0) and 25 other tissues

Gene size: 25644bp

Exon count: 18