Full name: ubiquitin-like modifier activating enzyme 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: A830034N06Rik; Ube1c

Summary: The protein encoded by this gene is the catalytic subunit of the enzyme that activates NEDD8, a ubiquitin-like molecule that binds to its target proteins through an enzymatic reaction analagous to ubiquitylation. Embryonic mice deficient for this protein die prior to implantation and display apoptosis of the inner cell mass. Trophoblastic cells cannot enter S phase, demonstrating that this gene is required for cell cycle progression during embryogenesis. Two pseudogenes have been found for this gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

Expression: Broad expression in CNS E11.5 (RPKM 17.1), placenta adult (RPKM 15.3) and 24 other tissues

Gene size: 22016bp

Exon count: 19