Full name: suppressor of cytokine signaling 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3

Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]

Expression: Broad expression in gall bladder (RPKM 130.8), urinary bladder (RPKM 79.6) and 21 other tissues

Gene size: 4148bp

Exon count: 4