Full name: suppressor of cytokine signaling 3

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Cis3; Cish3; EF-10; Ef10; SSI-3; Ssi3

Summary: Enables phosphotyrosine residue binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; negative regulation of insulin receptor signaling pathway; and placenta development. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including extraembryonic component; liver; placenta; retina; and spleen. Human ortholog(s) of this gene implicated in atopic dermatitis 4. Orthologous to human SOCS3 (suppressor of cytokine signaling 3). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in large intestine adult (RPKM 19.8), duodenum adult (RPKM 16.3) and 25 other tissues

Gene size: 3288bp

Exon count: 2