MAP3K14 mitogen-activated protein kinase kinase kinase 14 [ Homo sapiens (human) ] - Gene - Data resources

9020

MAP3K14 mitogen-activated protein kinase kinase kinase 14 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 9020)

Symbol: MAP3K14

Full name: mitogen-activated protein kinase kinase kinase 14

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: FTDCR1B; HS; HSNIK; NIK

Summary: This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in lymph node (RPKM 11.1), spleen (RPKM 8.5) and 25 other tissues

Orthologs: mouse

Gene size: 53902bp

Exon count: 17