Full name: delta like non-canonical Notch ligand 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DLK; DLK-1; Delta1; FA1; PREF1; Pref-1; ZOG; pG2

Summary: This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]

Expression: Biased expression in placenta (RPKM 382.3) and adrenal (RPKM 208.0)

Gene size: 11333bp

Exon count: 5