Full name: delta 4-desaturase, sphingolipid 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: DEGS; DEGS-1; DES1; Des-1; FADS7; HLD18; MIG15; MLD

Summary: This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010]

Expression: Broad expression in skin (RPKM 186.9), placenta (RPKM 50.2) and 21 other tissues

Gene size: 10202bp

Exon count: 5