Full name: lysyl-tRNA synthetase

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: D8Ertd698e; D8Wsu108e; Kars1; LysRS; mKIAA0070

Summary: Enables scaffold protein binding activity. Predicted to be involved in several processes, including ERK1 and ERK2 cascade; diadenosine tetraphosphate biosynthetic process; and lysyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in CNS E11.5 (RPKM 43.4), placenta adult (RPKM 35.9) and 28 other tissues

Gene size: 17916bp

Exon count: 17