Full name: lysyl-tRNA synthetase 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CMTRIB; DEAPLE; DFNB89; KARS; KARS2; KRS; LEPID

Summary: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in testis (RPKM 57.5), lymph node (RPKM 40.9) and 25 other tissues

Gene size: 19942bp

Exon count: 15