DOT1L DOT1 like histone lysine methyltransferase [ Homo sapiens (human) ]
Source: NCBI Gene (ID 84444)
Source: NCBI Gene (ID 84444)
Symbol: DOT1L
Full name: DOT1 like histone lysine methyltransferase
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Also known as: DOT1; KMT4
Summary: The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
Expression: Broad expression in testis (RPKM 18.3), bone marrow (RPKM 5.1) and 22 other tissues
Orthologs: mouse
Gene size: 68646bp
Exon count: 31