Dot1l DOT1-like, histone H3 methyltransferase (S. cerevisiae) [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 208266)
Source: NCBI Gene (ID 208266)
Symbol: Dot1l
Full name: DOT1-like, histone H3 methyltransferase (S. cerevisiae)
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: A630076O07; Dot1; KMT4; mDot1
Summary: Enables histone methyltransferase activity. Acts upstream of or within with a negative effect on gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including 1st branchial arch; blood; heart; sensory organ; and yolk sac. Used to study dilated cardiomyopathy 1A. Human ortholog(s) of this gene implicated in mixed phenotype acute leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 34.5), adrenal adult (RPKM 27.1) and 28 other tissues
Orthologs: human
Gene size: 40361bp
Exon count: 29