Full name: tRNA splicing endonuclease subunit 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: PCH2B; SEN2; SEN2L

Summary: This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]

Expression: Ubiquitous expression in ovary (RPKM 2.1), thyroid (RPKM 2.1) and 25 other tissues

Gene size: 59394bp

Exon count: 19