Full name: nucleoporin 85

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: FROUNT; NPHS17; Nup75

Summary: This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Expression: Ubiquitous expression in lymph node (RPKM 9.1), testis (RPKM 9.0) and 25 other tissues

Gene size: 30080bp

Exon count: 20