Full name: LDL receptor related protein 8

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: APOER2; HSZ75190; LRP-8; MCI1

Summary: This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

Expression: Biased expression in thyroid (RPKM 23.6), testis (RPKM 14.4) and 4 other tissues

Gene size: 85707bp

Exon count: 19