Lrp8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 16975)
Source: NCBI Gene (ID 16975)
Symbol: Lrp8
Full name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: 4932703M08Rik; ApoER2; Lr8b
Summary: Enables several functions, including amyloid-beta binding activity; apolipoprotein binding activity; and reelin receptor activity. Involved in several processes, including nervous system development; positive regulation of CREB transcription factor activity; and regulation of dendrite development. Acts upstream of or within central nervous system development and positive regulation of protein kinase activity. Located in cell surface and extracellular space. Is expressed in nervous system and retina layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 24.6), whole brain E14.5 (RPKM 23.2) and 14 other tissues
Orthologs: human
Gene size: 74701bp
Exon count: 25