Full name: mixed lineage kinase domain-like

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: 9130019I15Rik

Summary: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

Expression: Broad expression in bladder adult (RPKM 2.9), liver E18 (RPKM 1.8) and 21 other tissues

Gene size: 27203bp

Exon count: 12