Full name: mixed lineage kinase domain like pseudokinase

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: hMLKL

Summary: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]

Expression: Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 10.4) and 23 other tissues

Gene size: 29008bp

Exon count: 12