C5AR1 complement C5a receptor 1 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 728)
Source: NCBI Gene (ID 728)
Symbol: C5AR1
Full name: complement C5a receptor 1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Also known as: C5A; C5AR; C5R1; CD88
Summary: Enables G protein-coupled receptor activity and complement component C5a receptor activity. Involved in several processes, including complement component C5a signaling pathway; mRNA transcription by RNA polymerase II; and positive regulation of ERK1 and ERK2 cascade. Located in apical part of cell and basolateral plasma membrane. Biomarker of Alzheimer's disease; asthma; chronic obstructive pulmonary disease; rhinitis; and severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in appendix (RPKM 41.3), bone marrow (RPKM 38.2) and 11 other tissues
Orthologs: mouse
Gene size: 14590bp
Exon count: 4