Full name: complement component 5a receptor 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: C5aR; C5r1; Cd88; D7Msu1

Summary: Enables complement component C5a receptor activity. Involved in several processes, including astrocyte activation; positive regulation of vascular endothelial growth factor production; and regulation of granulocyte chemotaxis. Acts upstream of or within defense response to Gram-positive bacterium; neutrophil chemotaxis; and response to peptidoglycan. Predicted to be located in several cellular components, including apical part of cell; basolateral plasma membrane; and cell surface. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; liver; neural ectoderm; and sensory organ. Orthologous to several human genes including OPRPN (opiorphin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in lung adult (RPKM 10.0), mammary gland adult (RPKM 8.9) and 20 other tissues

Gene size: 12798bp

Exon count: 3