Full name: TIMP metallopeptidase inhibitor 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: HSMRK222; K222; K222TA2; SFD

Summary: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]

Expression: Broad expression in placenta (RPKM 485.4), fat (RPKM 420.5) and 18 other tissues

Gene size: 61337bp

Exon count: 5