Full name: tissue inhibitor of metalloproteinase 3

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Timp-3

Summary: Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of metalloendopeptidase activity. Acts upstream of or within cellular response to organic substance. Located in basement membrane. Is expressed in several structures, including alimentary system; central nervous system; eye posterior segment; genitourinary system; and musculoskeletal system. Used to study Sorsby's fundus dystrophy and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in kidney adult (RPKM 234.0), lung adult (RPKM 92.0) and 12 other tissues

Gene size: 49094bp

Exon count: 5