Full name: secreted phosphoprotein 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BNSP; BSPI; ETA-1; OPN

Summary: The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Expression: Biased expression in placenta (RPKM 1043.5), gall bladder (RPKM 1025.4) and 3 other tissues

Gene size: 7698bp

Exon count: 8