Full name: secreted phosphoprotein 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 2AR; Apl-1; BNSP; BSPI; Bsp; ETA-1; Eta; OP; Opn; Opnl; Ric; Spp-1

Summary: Enables extracellular matrix binding activity. Acts upstream of or within several processes, including cellular ion homeostasis; cellular response to leukemia inhibitory factor; and neutrophil chemotaxis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in kidney adult (RPKM 580.4), liver E18 (RPKM 36.2) and 1 other tissue

Gene size: 5943bp

Exon count: 8