Diablo diablo, IAP-binding mitochondrial protein [ Mus musculus (house mouse) ] - Gene - Data resources

66593

Diablo diablo, IAP-binding mitochondrial protein [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 66593)

Symbol: Diablo

Full name: diablo, IAP-binding mitochondrial protein

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 0610041G12Rik; 1700006L01Rik; Smac

Summary: Involved in positive regulation of apoptotic process. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; intrinsic apoptotic signaling pathway in response to oxidative stress; and neuron apoptotic process. Located in cytoplasmic side of plasma membrane and mitochondrion. Part of CD40 receptor complex. Is expressed in several structures, including cochlea; early conceptus; ganglia; pancreas epithelium; and trigeminal nerve. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 64. Orthologous to human DIABLO (diablo IAP-binding mitochondrial protein). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in testis adult (RPKM 115.4), ovary adult (RPKM 33.2) and 28 other tissues

Orthologs: human

Gene size: 15433bp

Exon count: 7