Full name: diablo IAP-binding mitochondrial protein

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DFNA64; SMAC

Summary: This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Expression: Ubiquitous expression in testis (RPKM 16.5), adrenal (RPKM 10.0) and 25 other tissues

Gene size: 19795bp

Exon count: 8