Full name: SOS Ras/Rac guanine nucleotide exchange factor 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: GF1; GGF1; GINGF; HGF; NS4; SOS-1

Summary: This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in fat (RPKM 10.4), ovary (RPKM 10.2) and 25 other tissues

Gene size: 143320bp

Exon count: 26