Full name: SOS Ras/Rac guanine nucleotide exchange factor 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 4430401P03Rik; 9630010N06

Summary: Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including animal organ development; regulation of T cell activation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in several cellular components, including neuronal cell body; plasma membrane; and postsynaptic density. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and retina. Used to study Noonan syndrome 4. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in CNS E18 (RPKM 5.3), cerebellum adult (RPKM 5.1) and 28 other tissues

Gene size: 86702bp

Exon count: 23