Full name: intersectin 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ITSN; SH3D1A; SH3P17

Summary: The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in fat (RPKM 8.8), brain (RPKM 4.1) and 24 other tissues

Gene size: 257361bp

Exon count: 44