Full name: intersectin 1 (SH3 domain protein 1A)

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Ehsh1; Ese1; Itsn; Sh3p17

Summary: Enables kinase activator activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within negative regulation of neuron apoptotic process; positive regulation of protein kinase B signaling; and small GTPase mediated signal transduction. Located in several cellular components, including calyx of Held; clathrin-coated pit; and lamellipodium. Is active in presynaptic endocytic zone. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human ITSN1 (intersectin 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in CNS E18 (RPKM 7.3), CNS E14 (RPKM 6.7) and 28 other tissues

Gene size: 191282bp

Exon count: 45