Full name: gremlin 2, DAN family BMP antagonist

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CKTSF1B2; DAND3; PRDC; STHAG9

Summary: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]

Expression: Broad expression in gall bladder (RPKM 20.4), colon (RPKM 11.9) and 14 other tissues

Gene size: 122583bp

Exon count: 5