Full name: secreted frizzled related protein 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: FRP; FRP-1; FRP1; FrzA; SARP2

Summary: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]

Expression: Broad expression in endometrium (RPKM 97.0), fat (RPKM 58.4) and 17 other tissues

Gene size: 47512bp

Exon count: 3