Full name: roundabout guidance receptor 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: SAX3

Summary: The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Expression: Broad expression in brain (RPKM 5.1), lung (RPKM 2.8) and 14 other tissues

Gene size: 1743290bp

Exon count: 34