NLRC4 NLR family CARD domain containing 4 [ Homo sapiens (human) ] - Gene - Data resources

58484

NLRC4 NLR family CARD domain containing 4 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 58484)

Symbol: NLRC4

Full name: NLR family CARD domain containing 4

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AIFEC; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; FCAS4; IPAF

Summary: This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Expression: Broad expression in appendix (RPKM 5.7), bone marrow (RPKM 3.2) and 17 other tissues

Orthologs: mouse

Gene size: 41295bp

Exon count: 10