Nlrc4 NLR family, CARD domain containing 4 [ Mus musculus (house mouse) ] - Gene - Data resources

268973

Nlrc4 NLR family, CARD domain containing 4 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 268973)

Symbol: Nlrc4

Full name: NLR family, CARD domain containing 4

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 9530011P19Rik; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; Card12; IPAF

Summary: Enables identical protein binding activity. Involved in several processes, including positive regulation of interleukin-1 beta production; protein homooligomerization; and response to bacterium. Acts upstream of or within regulation of apoptotic process and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytosol. Part of IPAF inflammasome complex. Used to study familial cold autoinflammatory syndrome 4. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 4. Orthologous to human NLRC4 (NLR family CARD domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in large intestine adult (RPKM 5.3), small intestine adult (RPKM 2.0) and 5 other tissues

Orthologs: human

Gene size: 32887bp

Exon count: 11