Full name: reticulon 4

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ASY; NI220/250; NOGO; NSP; NSP-CL; Nbla00271; Nbla10545; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C

Summary: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in fat (RPKM 122.1), brain (RPKM 104.7) and 24 other tissues

Gene size: 165643bp

Exon count: 17