Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 [ Mus musculus (house mouse) ] - Gene - Data resources

56508

Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 56508)

Symbol: Rapgef4

Full name: Rap guanine nucleotide exchange factor (GEF) 4

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 1300003D15Rik; 5730402K07Rik; 6330581N18Rik; EPAC 2; Epac-2; Epac2; mKIAA4040

Summary: Enables cAMP binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Involved in regulation of synaptic vesicle cycle. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Located in cytosol and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including adrenal gland; ganglia; heart; lung; and metanephros. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human RAPGEF4 (Rap guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in cortex adult (RPKM 46.5), frontal lobe adult (RPKM 40.1) and 5 other tissues

Orthologs: human

Gene size: 276260bp

Exon count: 35