Full name: Rap guanine nucleotide exchange factor 4

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: CAMP-GEFII; CGEF2; EPAC; EPAC 2; EPAC2; Nbla00496

Summary: Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of postsynapse organization. Predicted to act upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Implicated in autistic disorder. [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in brain (RPKM 37.0), adrenal (RPKM 17.3) and 12 other tissues

Gene size: 317576bp

Exon count: 37