Full name: histone deacetylase 8

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CDA07; CDLS5; HD8; HDACL1; KDAC8; MRXS6; RPD3; WTS

Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Expression: Ubiquitous expression in adrenal (RPKM 3.9), thyroid (RPKM 3.1) and 25 other tissues

Gene size: 243328bp

Exon count: 17