VPS11 VPS11 core subunit of CORVET and HOPS complexes [ Homo sapiens (human) ] - Gene - Data resources

55823

VPS11 VPS11 core subunit of CORVET and HOPS complexes [ Homo sapiens (human) ]
Source: NCBI Gene (ID 55823)

Symbol: VPS11

Full name: VPS11 core subunit of CORVET and HOPS complexes

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: END1; HLD12; HLD12; DYT32; PEP5; RNF108; hVPS11

Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Expression: Ubiquitous expression in thyroid (RPKM 16.0), bone marrow (RPKM 14.4) and 25 other tissues

Orthologs: mouse

Gene size: 14155bp

Exon count: 17