Full name: protein kinase AMP-activated catalytic subunit alpha 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: AMPK; AMPK2; AMPKa2; PRKAA

Summary: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]

Expression: Biased expression in heart (RPKM 14.0), kidney (RPKM 6.8) and 8 other tissues

Gene size: 70022bp

Exon count: 10