Full name: glutamate receptor, ionotropic, AMPA3 (alpha 3)

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: 2900064I19Rik; GluA3; GluR-C; GluR-K3; Glur-3; Glur3; Gluralpha3

Summary: This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutamate to promote synaptic transmission. Deficiency of this gene leads to behavioral phenotypes. The transcript is subject to RNA editing at codon 769 (AGA->GGA; R->G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Expression: Biased expression in frontal lobe adult (RPKM 31.4), cortex adult (RPKM 28.9) and 7 other tissues

Gene size: 278128bp

Exon count: 19